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10.1016/j.nrleng.2018.08.004 27 RiemannD.KroneL

doi: 10.1016/j.critrevonc.2017.01.004

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This mechanistic profile is why it appears in research spanning both areas

At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

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